Inhibition of neutrophil myeloperoxidase by rabbit anti-(human myeloperoxidase)
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چکیده
منابع مشابه
Cyanate-mediated inhibition of neutrophil myeloperoxidase activity.
Cyanate (CNO-) forms spontaneously in solutions containing urea, and is present in urine and the body fluids of uraemic patients. We have explored the possibility that CNO- might be one of the unknown substances responsible for the reported impairment, by urine and uraemic plasma, of neutrophil oxidative metabolism (especially as measured by luminol-enhanced chemiluminescence). Luminol-enhanced...
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Myeloperoxidase (MPO), H2O2, and chloride comprise a potent antimicrobial system believed to contribute to the antimicrobial functions of neutrophils and monocytes. The mechanisms of microbicidal action are complex and not fully defined. This report describes the MPO-mediated inactivation, in Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, of a class of cytoplasmic membrane...
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Organizing pneumonia (OP) is a clinicopathological entity that occurs idiopathically or in association with several conditions, but there are few reports about myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated OP. We describe a patient with OP whose clinical conditions improved spontaneously. Moreover, serum MPO-ANCA titers paralleled the clinical activity of the diseas...
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Salicylhydroxamic acid inhibited the luminol-dependent chemiluminescence of human neutrophils stimulated by phorbol 12-myristate 13-acetate or the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (fMet-Leu-Phe). This compound had no inhibitory effect on the kinetics of O2.- generation or O2 uptake during the respiratory burst, but inhibited both the peroxidative activity of purified m...
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II ABBIT HETEROPHIL LEUKOCYTES contain three distinctive types of granules, which have recently been designated primary, secondary, and tertiary granules according to their chronological appearance during cell development.’ The primary and secondary granules were conventionally designated azurophil and specific granules, respectively. Primary granules are present exclusively in early heterophil...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1989
ISSN: 0003-4967
DOI: 10.1136/ard.48.7.615